/* CSS Document */
body {
            font-family: 'Inter', sans-serif;
	max-width: 100%;
        }
        
        .gradient-bg {
            background: linear-gradient(135deg, #0066cc 0%, #004499 50%, #00aaff 100%);
        }
		.gradient-bg-alt {
  background: radial-gradient(circle at center, #00aaff 0%, #004499 50%, #0066cc 100%);
}
        
        .glass-effect {
            backdrop-filter: blur(10px);
            background: rgba(255, 255, 255, 0.1);
            border: 1px solid rgba(255, 255, 255, 0.2);
        }
        
        .chart-container {
            height: 400px;
        }
        
        .hover-scale {
            transition: transform 0.3s ease;
        }
        
        .hover-scale:hover {
            transform: translateY(-5px);
        }
        
        .nav-link {
            position: relative;
            transition: all 0.3s ease;
        }
        
        .nav-link::after {
            content: '';
            position: absolute;
            width: 0;
            height: 2px;
            bottom: -4px;
            left: 50%;
            background-color: #00aaff;
            transition: all 0.3s ease;
            transform: translateX(-50%);
        }
        
        .nav-link:hover::after,
        .nav-link.active::after {
            width: 100%;
        }
        
        .pulse-animation {
            animation: pulse 2s infinite;
        }
        
        @keyframes pulse {
            0%, 100% { opacity: 1; }
            50% { opacity: 0.7; }
        }
        
        .fade-in {
            opacity: 0;
            transform: translateY(20px);
            transition: all 0.6s ease;
        }
        
        .fade-in.active {
            opacity: 1;
            transform: translateY(0);
        }
        
        .typing-animation {
            overflow: hidden;
            border-right: 2px solid #00aaff;
            white-space: nowrap;
            animation: typing 3s steps(40, end), blink-caret 0.75s step-end infinite;
        }
        
        @keyframes typing {
            from { width: 0; }
            to { width: 100%; }
        }
        
        @keyframes blink-caret {
            from, to { border-color: transparent; }
            50% { border-color: #00aaff; }
        }
		.btn-animated-gradient {
  background: linear-gradient(270deg, #00aaff, #004499, #0066cc);
  background-size: 400% 400%;
  transition: all 0.5s ease;
}

.btn-animated-gradient:hover {
  background-position: right center;
}
        * {
            font-family: 'Inter', sans-serif;
        }
        
        .print-friendly {
            page-break-inside: avoid;
        }
        
         {
            .no-print {
                display: none !important;
            }
        }
        
        .biomarker-card {
            transition: all 0.3s ease;
            border-left: 4px solid #3B82F6;
        }
        
        .biomarker-card:hover {
            transform: translateY(-2px);
            box-shadow: 0 10px 25px rgba(0,0,0,0.1);
        }
        
        .iecc-score {
            display: inline-flex;
            align-items: center;
            justify-content: center;
            width: 30px;
            height: 30px;
            border-radius: 50%;
            color: white;
            font-weight: 600;
            font-size: 14px;
        }
        
        .score-excellent { background-color: #10B981; }
        .score-good { background-color: #3B82F6; }
        .score-moderate { background-color: #F59E0B; }
        .score-poor { background-color: #EF4444; }
        
        .evidence-level {
            font-weight: 600;
            padding: 2px 8px;
            border-radius: 4px;
            font-size: 12px;
        }
        
        .level-a { background-color: #10B981; color: white; }
        .level-b { background-color: #3B82F6; color: white; }
        .level-c { background-color: #F59E0B; color: white; }
        .level-d { background-color: #EF4444; color: white; }
        
        .impact-factor {
            font-weight: 600;
            padding: 2px 8px;
            border-radius: 4px;
            font-size: 12px;
        }
        
        .if-top { background-color: #7C3AED; color: white; }
        .if-high { background-color: #10B981; color: white; }
        .if-moderate { background-color: #F59E0B; color: white; }
        .if-basic { background-color: #6B7280; color: white; }
        
        .citation-count {
            font-weight: 600;
            padding: 2px 8px;
            border-radius: 4px;
            font-size: 12px;
        }
        
        .cite-fundamental { background-color: #7C3AED; color: white; }
        .cite-influential { background-color: #10B981; color: white; }
        .cite-recognized { background-color: #3B82F6; color: white; }
        .cite-emerging { background-color: #6B7280; color: white; }
        
        .sticky-header {
            position: sticky;
            top: 0;
            z-index: 50;
            background: white;
            border-bottom: 1px solid #E5E7EB;
        }
        
        .comparison-selected {
            border: 2px solid #3B82F6;
            background-color: #EFF6FF;
        }
        
        .chart-container {
            height: 400px;
            margin: 20px 0;
        }
        
        .filter-active {
            background-color: #3B82F6;
            color: white;
        }
        
        .accordion-content {
            max-height: 0;
            overflow: hidden;
            transition: max-height 0.3s ease;
        }
        
        .accordion-content.active {
            max-height: 1000px;
        }
        
        .glossary-item {
            border-left: 3px solid #3B82F6;
            padding-left: 12px;
            margin-bottom: 16px;
        }
        
        .search-highlight {
            background-color: yellow;
            font-weight: bold;
        }
        
        .table-responsive {
            overflow-x: auto;
            max-width: 100%;
        }
        
        .iecc-table {
            min-width: 1200px;
            font-size: 12px;
        }
        
        .iecc-table th {
            background-color: #F3F4F6;
            font-weight: 600;
            padding: 8px;
            text-align: left;
            white-space: nowrap;
        }
        
        .iecc-table td {
            padding: 8px;
            border-bottom: 1px solid #E5E7EB;
            vertical-align: top;
        }
        
        .performance-chart {
            height: 300px;
            margin: 20px 0;
        }
        
        .reference-item {
            border-left: 3px solid #10B981;
            padding-left: 12px;
            margin-bottom: 16px;
            background-color: #F9FAFB;
            padding: 12px;
            border-radius: 4px;
        }
        
        .doi-link {
            color: #3B82F6;
            text-decoration: none;
            font-weight: 500;
        }
        
        .doi-link:hover {
            text-decoration: underline;
        }
 :root {
            --primary-blue: #1e3a8a;
            --secondary-blue: #3b82f6;
            --light-blue: #eff6ff;
            --success-green: #10b981;
            --warning-orange: #f59e0b;
            --danger-red: #ef4444;
            --dark-bg: #1f2937;
            --dark-text: #f9fafb;
        }
        
        body {
            font-family: 'Inter', sans-serif;
            transition: all 0.3s ease;
        }
        
        .dark-mode {
            background-color: var(--dark-bg);
            color: var(--dark-text);
        }
        
        .dark-mode .bg-white {
            background-color: #374151 !important;
        }
        
        .dark-mode .text-gray-700 {
            color: #d1d5db !important;
        }
        
        .dark-mode .border-gray-200 {
            border-color: #4b5563 !important;
        }
        
        .font-mono {
            font-family: 'Roboto Mono', monospace;
        }
        
        .gradient-bg {
            background: linear-gradient(135deg, var(--primary-blue) 0%, var(--secondary-blue) 100%);
        }
        
        .criticality-critical {
            background: #fecaca;
            color: #991b1b;
        }
        
        .criticality-high {
            background: #fed7aa;
            color: #9a3412;
        }
        
        .criticality-moderate {
            background: #fef3c7;
            color: #92400e;
        }
        
        .score-high { background: #dcfce7; color: #166534; }
        .score-medium { background: #fef3c7; color: #92400e; }
        .score-low { background: #fee2e2; color: #991b1b; }
        
        .table-container {
            max-height: none !important;
            overflow: visible !important;
        }
        
         {
            .no-print { display: none !important; }
            body { -webkit-print-color-adjust: exact; }
        }
        
        .biomarker-name {
            display: flex;
            align-items: center;
            gap: 0.5rem;
        }
        
        .tnm-code {
            background: #f3f4f6;
            padding: 0.125rem 0.375rem;
            border-radius: 0.25rem;
            font-size: 0.75rem;
            font-weight: 500;
            color: var(--primary-blue);
        }
        
        .medical-certification {
            background: linear-gradient(135deg, #10b981 0%, #059669 100%);
            color: white;
            padding: 0.5rem 1rem;
            border-radius: 0.5rem;
            font-size: 0.875rem;
            font-weight: 600;
            display: inline-flex;
            align-items: center;
            gap: 0.5rem;
        }
        
        .pubmed-link {
            color: #2563eb;
            text-decoration: none;
            font-weight: 500;
        }
        
        .pubmed-link:hover {
            text-decoration: underline;
        }
        
        .dark-mode-toggle {
            position: fixed;
            top: 20px;
            right: 20px;
            z-index: 1000;
            background: var(--primary-blue);
            color: white;
            border: none;
            border-radius: 50%;
            width: 50px;
            height: 50px;
            cursor: pointer;
            font-size: 1.2rem;
            transition: all 0.3s ease;
        }
        
        .dark-mode-toggle:hover {
            background: var(--secondary-blue);
        }
        
        .breadcrumb {
            background: #f8fafc;
            padding: 0.75rem 1.5rem;
            border-radius: 0.5rem;
            margin-bottom: 1rem;
            font-size: 0.875rem;
        }
        
        .breadcrumb a {
            color: var(--primary-blue);
            text-decoration: none;
        }
        
        .breadcrumb a:hover {
            text-decoration: underline;
        }
        
        .ssl-indicator {
            position: fixed;
            bottom: 20px;
            right: 20px;
            background: #10b981;
            color: white;
            padding: 0.5rem 1rem;
            border-radius: 0.5rem;
            font-size: 0.75rem;
            font-weight: 600;
            z-index: 1000;
        }
        
        .performance-indicator {
            position: fixed;
            bottom: 20px;
            left: 20px;
            background: #3b82f6;
            color: white;
            padding: 0.5rem 1rem;
            border-radius: 0.5rem;
            font-size: 0.75rem;
            font-weight: 600;
            z-index: 1000;
        }
        
        .webp-optimized {
            background: url('data:image/webp;base64,UklGRiIAAABXRUJQVlA4IBYAAAAwAQCdASoBAAEAAwA0JaQAA3AA/vuUAAA=') no-repeat;
            background-size: cover;
        }
.ihc-submenu{
	width: 80%;
	padding: 15px;
}

 :root {
            --primary-color: #1e40af;
            --secondary-color: #3b82f6;
            --accent-color: #60a5fa;
            --success-color: #10b981;
            --warning-color: #f59e0b;
            --error-color: #ef4444;
            --text-dark: #1f2937;
            --text-light: #6b7280;
            --bg-light: #f9fafb;
            --bg-white: #ffffff;
            --border-color: #e5e7eb;
            --shadow-sm: 0 1px 2px 0 rgb(0 0 0 / 0.05);
            --shadow-md: 0 4px 6px -1px rgb(0 0 0 / 0.1), 0 2px 4px -2px rgb(0 0 0 / 0.1);
            --shadow-lg: 0 10px 15px -3px rgb(0 0 0 / 0.1), 0 4px 6px -4px rgb(0 0 0 / 0.1);
            --border-radius: 0.5rem;
            --transition: all 0.3s ease;
        }
        
        * {
            margin: 0;
            padding: 0;
            box-sizing: border-box;
        }
        
        body {
            font-family: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
            line-height: 1.6;
            color: var(--text-dark);
            background-color: var(--bg-white);
            font-size: 16px;
        }
        
        .skip-link {
            position: absolute;
            top: -40px;
            left: 6px;
            background: var(--primary-color);
            color: white;
            padding: 8px 16px;
            text-decoration: none;
            z-index: 1001;
            border-radius: var(--border-radius);
            transition: var(--transition);
        }
        
        .skip-link:focus {
            top: 6px;
        }
        
        .sr-only {
            position: absolute;
            width: 1px;
            height: 1px;
            padding: 0;
            margin: -1px;
            overflow: hidden;
            clip: rect(0, 0, 0, 0);
            white-space: nowrap;
            border: 0;
        }
        
        .gradient-text {
            background: linear-gradient(135deg, var(--primary-color), var(--secondary-color));
            -webkit-background-clip: text;
            -webkit-text-fill-color: transparent;
            background-clip: text;
        }
        
        .card {
            background: white;
            border-radius: var(--border-radius);
            box-shadow: var(--shadow-sm);
            transition: var(--transition);
            border: 1px solid var(--border-color);
        }
        
        .card:hover {
            box-shadow: var(--shadow-md);
            transform: translateY(-2px);
        }
        
        .btn {
            display: inline-flex;
            align-items: center;
            gap: 0.5rem;
            padding: 0.75rem 1.5rem;
            border-radius: var(--border-radius);
            font-weight: 500;
            text-decoration: none;
            transition: var(--transition);
            cursor: pointer;
            border: none;
        }
        
        .btn-primary {
            background: var(--primary-color);
            color: white;
        }
        
        .btn-primary:hover {
            background: var(--secondary-color);
            transform: translateY(-1px);
        }
        
        .table-responsive {
            overflow-x: auto;
            border-radius: var(--border-radius);
            border: 1px solid var(--border-color);
        }
        
        .table {
            width: 100%;
            border-collapse: collapse;
            background: white;
        }
        
        .table th,
        .table td {
            padding: 1rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .table th {
            background: var(--primary-color);
            color: white;
            font-weight: 600;
        }
        
        .table tbody tr:hover {
            background: var(--bg-light);
        }
        
        .nav-tabs {
            border-bottom: 1px solid var(--border-color);
        }
        
        .nav-tab {
            display: inline-block;
            padding: 0.75rem 1.5rem;
            margin-bottom: -1px;
            background: transparent;
            border: 1px solid transparent;
            border-bottom: none;
            color: var(--text-light);
            text-decoration: none;
            cursor: pointer;
            transition: var(--transition);
        }
        
        .nav-tab.active {
            color: var(--primary-color);
            border-color: var(--border-color);
            border-bottom-color: white;
            background: white;
        }
        
        .tab-content {
            display: none;
            padding: 2rem;
        }
        
        .tab-content.active {
            display: block;
        }
        
        .score-badge {
            display: inline-flex;
            align-items: center;
            padding: 0.25rem 0.75rem;
            border-radius: 9999px;
            font-weight: 500;
            font-size: 0.875rem;
        }
        
        .score-high {
            background: #dcfce7;
            color: #166534;
        }
        
        .score-medium {
            background: #fef3c7;
            color: #92400e;
        }
        
        .score-low {
            background: #fee2e2;
            color: #991b1b;
        }
        
        .progress-bar {
            width: 100%;
            height: 0.5rem;
            background: var(--bg-light);
            border-radius: 9999px;
            overflow: hidden;
        }
        
        .progress-fill {
            height: 100%;
            background: linear-gradient(90deg, var(--primary-color), var(--secondary-color));
            border-radius: 9999px;
            transition: width 0.5s ease;
        }
        
        @media (max-width: 768px) {
            .container {
                padding-left: 1rem;
                padding-right: 1rem;
            }
            
            .grid {
                grid-template-columns: 1fr;
            }
            
            .text-5xl {
                font-size: 2.5rem;
            }
            
            .text-3xl {
                font-size: 1.875rem;
            }
        }
        
        @media (prefers-reduced-motion: reduce) {
            * {
                animation-duration: 0.01ms !important;
                animation-iteration-count: 1 !important;
                transition-duration: 0.01ms !important;
            }
        }
        
        .print-break {
            page-break-inside: avoid;
        }
        
         {
            .no-print {
                display: none !important;
            }
            
            body {
                font-size: 12px;
                line-height: 1.4;
            }
            
            .container {
                max-width: none;
                padding: 0;
            }
            
            .card {
                border: 1px solid var(--border-color);
                box-shadow: none;
            }
        }
        
        .collapsible {
            cursor: pointer;
            user-select: none;
        }
        
        .collapsible-content {
            max-height: 0;
            overflow: hidden;
            transition: max-height 0.3s ease;
        }
        
        .collapsible-content.active {
            max-height: 1000px;
        }
        
        .chart-container {
            position: relative;
            height: 400px;
            margin: 2rem 0;
        }